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Release of hydrogen peroxide (H 2 O 2 ) in CSE increases with the tar content of cigarettes and leads to progressive oxidative damage in BBB ECs TS is a major exogenous source of free radicals contained in both gaseous phase and tar, which can spawn sustained high levels of ROS (e.g., H 2 O 2 ) that may directly affect the BBB integrity

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[ 5 ] In fact, young adults aged 18 to 24 account for 55% of all hookah smokers in the United States

15 years for the risk of heart attack and stroke to be roughly equivalent to a person who has never smoked

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