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In 1950s, the link between tobacco smoking and lung cancer was established, but it was still not clear which components of smoke were mainly tumorigenic

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Not long after that finding went public, the American Nonsmokers Rights Foundation (ANRF) and a handful of partners in the health care industry who own shares in Boyd Gaming, Caesars Entertainment, Penn Entertainment and Wynn Resorts submitted shareholder proposals calling for investors to ask operators to commission and disclose a report on the potential cost savings of smoke-free policies

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It is the norm in epidemiologic research for risks among exposed groups to be compared with risks among a referent, nonexposed group