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Out of the 53 SNPs, 34 (64.1%) were confirmed to be associated with CPD in GERA, including 15 at a Bonferroni-corrected alpha level of 9.43 10 4 (0.05/53) (Supplementary Data 2)

Persistent SNS overactivity induces functional and structural changes in various organs, like heart and blood vessels ( Smoking is the most preventable cause of CVD and is involved in all steps of the above cascade (Roy et al., 2017)

They are also interested in exploring further the effect of passive smoke exposure on tissue self-repair, regeneration and ageing, particular in the way that it could affect children