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FIGURE 1 2 Combination therapy with 5-ASA and TCM for UC 2.1 Combination of natural bioactive compounds with 5-ASA: multidimensional regulation and delivery enhancement The combination of natural bioactive compounds with 5-ASA represents a significant advancement in UC therapy, aligning with the emerging trend toward multi-target regulation and synergistic efficacy

Acute musculoskeletal injuries (tendon strains and muscle tears) show functional improvement from 2 to 4 weeks, while full collagen remodeling requires 4 to 6 weeks of consistent administration

Numerous studies have highlighted the cytotoxic effects of ROS inducers on cancer cells by promoting oxidative cell death

NADPH oxidase-mediated reactive oxygen species production activates hypoxia-inducible factor-1 (HIF-1) via the ERK pathway after hyperthermia treatment

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