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The addict may become hyperactive and talk incessantly

Another study on human organotypic oral epithelial cultures showed that IQOS, compared to CS, yielded less cytotoxicity (significant after 48 h post-exposure), secretion of proinflammatory mediators, and gene expression perturbations related to apoptosis, necroptosis, senescence, xenobiotic metabolism, and oxidative stress 58

Individual Factors : Age, liver function, and metabolic rate can influence how quickly nicotine is cleared from the body

Seeking guidance from a therapist may be helpful to explore other issues that may be contributing to your smoking habit and work on your triggers