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As shown in Figure 5B5F, characteristic morphological changes were observed in lung sections after LPS administration, including notable immune cell infiltration, interstitial edema, alveolar wall thickness, and hemorrhage

Emerging evidence firmly establishes that the disruption of copper homeostasis is a significant contributor to this process, driving aortic wall degeneration through interconnected pathways involving oxidative damage, inflammation, vascular dysfunction, and metabolic defects [208]

Phase Cag introduction Weeks 9-12 Retatrutide 4 mg/week (hold) Cagrilintide 0.25 mg/week Notes Add cagrilintide at the lowest dose

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