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Although large-scale orthopaedic trials are lacking, animal studies and indirect clinical evidence provide a biologic rationale for their use

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These treatments mitigate the adverse effects of cellular senescence, such as inflammation and organ decline over time

Non-optimised filling parameters can lead to losses and a high reject rate during visual inspection due to a high fill-weight variability or filling needle clogging, which can potentially lead to abortion of the filling process and the need to discard the remaining bulk solution

doi: 10.3389/fncel.2022.985943 Received 04 July 2022 Accepted 20 October 2022 Published 10 November 2022 Volume 16 - 2022 Edited by Silvia Snchez-Ramn, Complutense University of Madrid, Spain Reviewed by Jorge Matias-Guiu, Complutense University of Madrid, Spain