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Healthcare providers should work closely with patients to optimize dosing based on individual response patterns, treatment goals, and tolerance

Adipose tissue can directly express hepcidin and can also indirectly regulate the expression of hepcidin through the levels of leptin and proinflammatory cytokines to affect iron balance

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Water distribution depends primarily on the concentration of electrolytes in the body compartments and sodium (Na +) plays a major role in maintaining physiologic equilibrium