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A study showed that male mice with prenatal e-cigarette exposure showed a decrease in occludin and claudin-5 expression, with reduced astrocyte numbers, increased inflammatory response in the hippocampus, and decreased learning and recognition memory evaluated by the Novel Object Recognition test and Morris Water Maze test at adolescence and adult age (Archie et al., 2023)

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Her death worsened an already terrible economic condition for the family, especially since the loss of Arthur Tolkien, the familys single source of income