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Due to a technical improvement in the cotinine assay, the cotinine LOD decreased from 0.05 to 0.015 ng/mL during Period 2

Passive (a.k.a., experimenter-administered) exposure allows for the control of both dose and time of administration relative to other outcome measures (e.g., examination of brain activation after a discrete time period) (60)

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In eight EU countries, 9% of surveyed smokers had quit completely after the EU flavor ban, while 5% had moved to menthol cigarettes and 62% had moved to unflavored cigarettes