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Notably, these associations were stronger among female adolescents, suggesting potential sex-specific vulnerability to the psychological effects of vaping ( Furthermore, the high nicotine concentrations found in some e-cigarette productsoften exceeding those of traditional cigarettespose a substantial risk for dependence and addiction ( Despite the presence of nicotine in most e-cigarette products ( Taken together, these findings highlight how nicotine exposure through e-cigarettes jeopardizes both mental health and neurodevelopment in adolescents while reinforcing dependence through neurochemical and behavioral mechanisms