According to the revenue authority, the illegal tobacco trade in cigarettes is a priority area and much focus is placed to perform audits, investigations where required, and [eventually] take appropriate legal actions. T&T implementation postponed again But legal prosecution aside, what South Africa requires above all else is a reliable tracking system to monitor cigarette manufacturing volumes as an effective countermeasure against tax dodging
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Further, as demonstrated by -Trcp1/2, there is significant redundancy in the substrate recognition system, meaning that identification of substrates unique to each E3 ligase may be required to facilitate efficient small-molecule inhibition of substrate degradation
