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Damaged cilia mean the lungs are less able to defend themselves, making breathing harder and reducing stamina for everyday activities
Helping fuel the decline: a series of stiff public health measures that raised cigarette taxes, required uniform packaging free of branding and mandated graphic warning labels
Mitochondria play an important role in multiple cellular senescence mechanisms (van Deursen, 2014), and in senescent cells we can observe changes in mitochondria, including morphological changes such as increase in size, loss of mitochondrial cristae, and accumulation of mitochondrial ROS, with mutations in mtDNA, collectively known as senescence-associated mitochondrial dysfunction (SAMD)
but I am not sure that the data convinces me