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M1 macrophages are involved in the immune response and immune monitoring through antigen presentation and the release of pro-inflammatory cytokines like IL-1 and TNF- (87)

This effect has been observed in vitro in various tumor cell lines including human osteosarcoma cells, fibrosarcoma cells, glioblastoma cells, pancreatic cancer cells and colon cancer cells with EGFR signaling pathway being of great significance [166,167,168,169,170,171,172]

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