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In dysfunctional mitochondria, the decoupling of electron transport chain leads to ROS production and ATP depletion, causing extensive damage to cardiomyocytes and activating cell apoptosis or necrosis [77]

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Cell 126:349359 Yamada Y, Tomaru U, Ishizu A, Ito T, Kiuchi T, Ono A, Miyajima S, Nagai K, Higashi T, Matsuno Y, Dosaka-Akita H, Nishimura M, Miwa S, Kasahara M (2015) Decreased proteasomal function accelerates cigarette smoke-induced pulmonary emphysema in mice

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