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Among the EU Member States, only in Croatia did heavy smokers make up the majority of daily smokers

Directorate for Health and Social Affairs

Although these researchers also found no significant differences in bronchial microbiome between stability and exacerbation using 16S rRNA sequencing and shotgun metagenomic sequencing, functional metabolic capabilities showed significant changes in several pathways, indicating specific changes in the lung microbiome in the progression of COPD [82]

18 more per 1000, 95% CI 1 to 41 more), and tailored (10 RCTs, n = 14 259

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