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However, as compared to the addition of CSE into NS, the MAOA inhibition of non-nicotine constituents might be an important factor for the enhancement on nicotine, which would lead to stronger DA release and reinforcement properties

Some key biological causes include: Neurochemical Changes : Nicotine binds to nicotinic acetylcholine receptors in the brain, particularly the 42 subtype, stimulating the release of dopamine and other neurotransmitters that create pleasurable sensations and reinforce smoking behavior