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Future work may need to improve these smoking intervention messages to not only appeal to those who are already highly motivated to quit, but also to those who report indicators of high nicotine dependence or who may be less motivated to quit

17 However, subsequent meta-analyses have not established a causal link, with rates of reported serious adverse effects in RCTs being similar between varenicline, NRT and placebo

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Growing demand for flavored tobacco products, increased popularity among young consumers, and growing distribution networks are fueling market growth in Asia-Pacific, North America, and regions of Europe