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ZO-1 is a cytoplasmic accessory protein which plays a crucial role in BBB integrity by connecting transmembrane proteins (such as occludin, claudins and JAM) to cytoskeletal proteins and is actively involved in signal transduction and transcriptional modulation [45, 46]

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Gastroenterology 2019: Epidemiology, pathophysiology, and treatment of diverticulitis [expert review, ungraded] American Journal of Gastroenterology 2015