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The headline results, as released in the Eli Lilly investor communication and aligned with the study design paper by Giblin and colleagues published in Diabetes, Obesity and Metabolism in 2026, are unusually strong for a Phase 3 obesity trial: Retatrutide 12 mg: mean body-weight reduction of 28.7 percent, roughly 32.3 kg (about 71.2 lbs) from baseline

This is because L-carnitine aids fat metabolism by bringing fatty acids into the mitochondria of cells where theyre burned for energy, Zenker says

PMID 24748564

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This benefit is particularly important for individuals with compromised immune systems, such as the elderly, those with chronic illnesses, or individuals recovering from surgery or injury