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While smoking is by far the leading cause of lung cancer, other risk factors may increase a persons chances of developing the disease, including: Second-hand smoke Radon exposure Asbestos exposure Cancer-causing agents in the workplace, including radioactive ores (uranium), arsenic, vinyl chloride, nickel chromates, coal products, mustard gas, chloromethyl ethers and diesel exhaust Personal or family history of lung cancer Air pollution Smoking is hands down the number one cause of lung cancer, but we also see plenty of patients with lung cancer who have never smoked a day in their lives, Crawley says