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[57] Long-term nicotine exposure upregulates cortical nicotinic receptors, but it also lowers the activity of the nicotinic receptors in the cortical vasodilation region

Denoting the rsfMRI data of one voxel by x = [ x 1 , x 2 , , x N ], where N is the number of acquisitions, SampEn calculation starts with forming a series of vector sequences, each with m consecutive points extracted from x : u i = [ x i , x i +1, , x i + m 1], where i = 1( N m + 1), and m is the pre-defined window size (3, as stated above)

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Nicotine-free pouches are not entirely safe from counterfeiting either, as they can contain the synthetic nicotine analog 6-methyl nicotine at up to 20mg per pouch (Vanhee et al., Drug Testing and Analysis, 2025), with no UK regulatory oversight