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Furthermore, nicotine has been shown to induce endothelial damage and apoptosis [23], with other studies suggesting that nicotine consumption through ENDS promotes tissue remodeling, causing vascular dysfunction via damaged endothelium [24]

While IQOS is a Phillip Morris International product, it is licensed to be sold and marketed in the U.S

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We also pre-tested these with multiple native speakers to ensure translations were accurate, and the training provided to data collectors and data collection were conducted in Chinese

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