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Furthermore, studies have shown that, as a regulatory mechanism, there is an increase in expression of GLUT1 through activation of phosphoinositide-3 kinase (PI3K)/Akt pathway via hypoxia-inducible factor-1 (HIF-1) (Yeh et al., 2008)

For example, people who smoke more than 10 cigarettes a day may start on a higher-dose, 21 mg patch

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4.1 Study limitations We recognize the limitation in our studys design as we conducted a nationwide online survey through the Rakuten Insights platform, including a panel of around 315,000 Filipinos