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Chronic inflammation, in turn, can further impair mitochondrial function, creating a vicious cycle

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They attributed these differences to the effects of sex hormones and immune reactions, explaining that men have increased overall inflammation in old age due to declining levels of testosterone, while women with fibromyalgia often have growth hormone deficiencies, leading to a decrease in estrogen production in early adulthood that would otherwise protect against neuroinflammation until menopause-related declines