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The worlds five major tobacco companies are thriving, profitable and increasing sales, despite many predictions of the industrys decline A casual observer could be forgiven for believing that the tobacco industry for so long a fixture as permanent as its two main by-products, death and taxes is itself on its last legs

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However, research indicates that smoking can negatively impact the expression and functional activity of ABCA1 in individuals with CHD, leading to cholesterol accumulation in macrophages [167]