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White-matter changes appear to be asymmetrical and present in the earliest stages of bipolar illness, most likely indicating abnormal expression of myelin- and oligodendrocyte-related genes (128131, 133, 134)
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Non-coding RNAs add further regulatory complexity: specific miRNA profiles (let-7 family, miR-372373 cluster) correlate with oocyte competence and embryo potential [170,171,172,173,174,175,176], while long non-coding RNAs such as NORAD and NEAT1 regulate chromatin organization [177,178,179,180]
& Klareskog, L
To minimize off-target effects and cell type-specific phenomena, three GBM cell lines (U373, U87, and HS683) with high endogenous SYNCRIP expression were selected for gene editing
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