First, viral infections predisposed the respiratory epithelium to bacterial colonization by inducing the overexpression of host surface receptors, such as platelet-activating factor receptor (PAFR) and intercellular adhesion molecule 1 (ICAM-1)
The beneficial therapeutic effects of UA in acute and chronic forms of mouse experimental allergic encephalomyelitis (EAE) have also been shown [156]
Pretreatment with losartan significantly improves FST performance and prevents LPS-induced anhedonia and anxiety-like behaviors in addition to preventing LPS-induced higher levels of the pro-inflammatory cytokine (TNF, IL-1, and IL-6) (99, 116)
Future research will need to clarify the extent to which these mechanisms are translatable into clinical practice and what their long-term implications may be for the human population
Science and theory are exciting, but as a practical, health-conscious consumer, you likely want to know how this actually feels in the real world
