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"Subjects who stopped smoking seem to partially recover their cortical thickness for each year without smoking." But the damage may never be fully repaired, with the study showing that former heavy smokers who quit more than 25 years ago still have thinner cortices than people who never smoked

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Balbo S, James-Yi S, Johnson CS, OSullivan MG, Stepanov I, Wang M, et al

In group 3, an increase in mitral A a and tricuspid A a , and a reduction in mitral E a /A a ratio, tricuspid E a , and tricuspid E a /A a ratio were observed after sequential caffeine assumption and cigarette smoking (Figures 3, 4, bottom panels)