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Any genetic and non-genetic alteration in active and passive force generation at the sarcomere level might lead to electrical dysfunction via altered myofilament Ca 2+ -sensitivity, sarcomere integrity, impaired contractility and disturbed coordination of signalling molecules, all of which could induce and maintain AF by causing reentry-promoting atrial remodeling (300, 301)

To accomplish these objectives, NATO: --Focuses on protecting the right of retailers to sell and the right of adults to purchase and enjoy tobacco products

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This is a legal form that was released by the Virginia Department of Taxation - a government authority operating within Virginia