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Only six reproducible, genome-wide significant loci have been identified: CHRNB3-CHRNA6 (chr8p11), DBH (chr9q34), CHRNA5-CHRNA3-CHRNB4 (chr15q25), DNMT3B and NOL4L (chr20q11), and CHRNA4 (chr20q13) 6

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Two in five school-going adolescents are purchasing loose cigarettes 2

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Specifications: - Body Shape: ES-335 - Body Style: Semi-Hollow Body - Body Material: Maple/Poplar/Maple - Body Finish: Gloss Nitrocellulose Lacquer - Color: Vintage Tobacco Burst - Binding: Single-Ply Cream Top and Back - Neck Material: Mahogany - Neck Profile: Rounded C - Neck Joint: Glued-In Set Neck - Fingerboard Material: Rosewood - Fingerboard Radius: 12" - Number of Frets: 22 - Fret Size: Medium Jumbo - Inlays: Acrylic Dot - Nut Material: Graph Tech - Scale Length: 24.75" - Bridge: ABR-1 Tune-O-Matic - Tailpiece: Aluminum Stop Bar - Tuning Machines: Vintage Deluxe with Keystone Buttons - Hardware Finish: Nickel - Pickguard: '59 Style 5-Ply Long Pickguard - Control Knobs: Gold Top Hats with Dial Pointers - Neck Pickup: Custombucker Alnico 3 - Bridge Pickup: Custombucker Alnico 3 - Controls: 2 Volume, 2 Tone, Hand-Wired with 500K Potentiometers and Orange Drop Capacitors - Switching: 3-Way Toggle - Case: Gibson Hardshell Case Sku: ES35500ETNH1