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We were interested in testing how varenicline altered the long-lasting effects of nicotine on nAChRs and determining whether this process involved nAChRs inside of cells. In the brain, there is an upregulation (an increase in number and sensitivity) of nAChRs as they adapt to chronic nicotine

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These can include: Feeling irritable, jumpy, restless, or anxious Feeling sad or down Having trouble sleeping Having a hard time concentrating Feeling hungry Having an upset stomach Craving nicotine Learn more at: How Smoking and Nicotine Damage Your Body (American Heart Association) Nicotine Addiction (Health Canada) Nicotine is particularly harmful for youth because it can harm brain development and change brain chemistry

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