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In total, seven TNP categories were explored, allowing for the assessment of measurement comparability across a large spectrum of TNPs and providing a solid foundation for the measure to be used with other products (e.g., heated tobacco products and nicotine pouches)

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For voxel-based morphometry (VBM), the images were first segmented into gray matter, white matter and cerebrospinal fluid tissue maps with the VBM8 toolbox ( Then the gray matter maps were used to generate the study-specific template by the DARTEL algebra 60