The same parts of the brain where other addictive medications generate a neurotransmitter called dopamine are also affected by nicotine
But, I think in the framework of the story, James is the naive window from which the world is entered
Stored in a well-maintained humidor, a cigar can stay in good smoking condition for years or even decades
They ship in a slim rectangular can, 20 pouches at a time, and the strength range is the widest out there: 1.5mg, 2mg, 4mg, and 8mg
Even conditions that would otherwise be perceived as nonclinical, such as a patient is noncompliant with medications due to financial reasons (code Z91.12x), should be documented and reported, because this may explain why the outcome does not meet industry expectations