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MIS is the main line of defense for the mucosal surfaces that line the digestive system, where most human and animal infections start infecting people

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By the way, according to the Cambridge dictionary, E-CIGARETTE means an electronic device that looks like a cigarette and allows someone to breathe in nicotine (= the drug found in tobacco) using vapour (= gas from heated water) rather than smoke, so there is no tar (= the harmful black substance produced when tobacco burns)