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A significant increase in SerpinA5 within the subchondral bone of OA patients has been observed, suggesting that the disruption of coagulation and complement pathways plays a role in the progression of OA and may provide a potential therapeutic target for the disease [61]

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Whether that gain holds up against retatrutide's already-stronger backbone is the open empirical question additive effects often diminish as the base compound's efficacy increases

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