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Tashiro Y, Yawata Y, Toyofuku M, Uchiyama H, Nomura N (2013) Interspecies interaction between Pseudomonas aeruginosa and other microorganisms

A randomized controlled trial study is the best method for verifying causality, but it is lengthy, expensive, and fraught with problems, so a successful approach is to use genetic variants as exposure indicators that are not subject to the influences that compromise conventional study designs, an approach known as Mendelian randomization (MR) (14, 15)

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Such improvements are short-lived, however, and the brain quickly adapts to the levels of nicotine

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