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5 The microvessels that perfuse this area are injured, and permeability is increased, resulting in leakage of large amounts of plasma into the interstitium

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Hence joint diseases are common in smokers

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"Sanidad inicia el trmite para eliminar las marcas de las cajetillas de tabacco y que todas sean iguales" [Health starts the procedure to eliminate branding from tobacco packs so that all look the same] (in European Spanish)