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Here, sequence analysis of 16S rDNA revealed a reduction of Firmicutes and Bacteroidetes and an increase of Actinobacteria and Proteobacteria (33)

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Although the adjusted smoking rate does not add in those who reported current use of vapes or using NRT products in the past 7 days as these can also impact cotinine levels, use of other products containing nicotine (such as nicotine pouches) could be impacting these results

Proposed Effective Dates XI

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