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Some of the physical effects of nicotine withdrawal are as follows: Difficulty concentrating Anxiety or panic attacks Increased depression or mania Increased irritability, anger, or frustration Fluctuations in appetite and weight gain Increase in environmental triggers that spur tobacco use While nicotine is not normally associated with the same level of risk as alcohol or other hard drugs which require serious drug and alcohol rehab centers in WV, it can be just as hard to kick and even more deadly