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The IGF-1/PI3K/Akt signaling pathway is not only capable of activating anabolic pathways, but also of suppressing catabolic pathways, due to an inactivation of a specific transcription factor family called forkhead box-O transcription factors (FOXO) [53]

When brain tissue damage occurs, the cytoskeleton of cells increases the protein GFAP (Panickar and Norenberg 2005)

Therefore, hypoxia acts as a factor that worsens (or is exacerbated by) lipotoxicity and, importantly, it could be a link between simple steatosis and NASH

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This mechanistic complementarity is the basis for the rumor of the Wolverine combo, although no peer-reviewed study has yet validated the combo itself