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We have demonstrated high levels of SVCT2 expression in pyramidal neurons of the inner region of the cerebral cortex, mainly between the postnatal stages P1 and P5 (Figure 1), SVCT2 is not present in most parenchymal astrocytes ( in vitro (Ulloa et al., 2013, 2019), confirming the participation of the choroid plexus-CSF barrier in the entry of vitamin C into the brain (Figure 1)

Cell Death Dis 14:519 Liu Z, Nan P, Gong Y, Tian L, Zheng Y, Wu Z (2023c) Endoplasmic reticulum stress-triggered ferroptosis via the xbp1-hrd1-nrf2 pathway induces emt progression in diabetic nephropathy

These enzymes are essential for scavenging ROS and mitigating the harmful effects of oxidative stress

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