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The villains mostly smoked cigars and in the first series it even served as a kind of marker, until Roger Moore broke the pattern with his whimsy)) However, there was another famous smoker in this spy saga it was M, the head of Mi-6 and Bonds immediate superior

Environmental tobacco smoke and tobacco related mortality in a prospective study of Californians, 196098

References 1World Health Organization

For example, anti-arrhythmic drugs (used to treat abnormal heart rhythms), digitalis, asthma medications, thyroid drugs, steroid therapy and most cold/cough remedies commonly trigger faster heart rates

Ironically, the first role Jackson would take as a sober actor would require him to play a crack addict