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On the other hand, decreased production of TCA cycle metabolites such as succinate and fumarate as a result of KGDHC inhibition by CSE treatment might reduce the transcriptional activity of HIFs also under normoxia [44, 54, 55]

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Although some cigars are cut on both ends, or twirled at both ends, the vast majority come with one straight cut end and one end in a "cap" which must be cut off for the cigar to be smoked