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Addressing these gaps requires multi-dimensional studies integrating single-cell omics, spatial transcriptomics, and clinical cohort analyses to resolve pathway crosstalk, define cell type-specific roles, and bridge preclinical and clinical translation, ultimately advancing ferroptosis-targeted strategies from bench to bedside in AKI treatment
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However, further prospective cohort studies with clinical endpoints in healthy subjects, and results from on-going randomized, placebo-controlled interventional trials are awaited to truly define the efficiency of homocysteine-lowering therapy in the prevention and correction of vascular disorders among patients with occlusive coronary artery, cerebrovascular and peripheral vascular diseases, and thrombosis related to hyperhomocysteinemia
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Glutathione is a tripeptide composed of three amino acids cysteine, glycine, and glutamic acid
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