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Metalloproteinase regulation: It promotes the production of enzymes that break down and remove damaged, disorganized collagen the kind that accumulates with age and UV exposure while simultaneously stimulating the production of new, organized collagen in its place

Over five million patients are treated with TS inhibitors annually 89,90 , expanding our findings beyond the CRC field to other disease indications that use pemetrexed or methotrexate, such as lung cancer

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