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This persistently high prevalence of cigarette use still the countrys leading cause of preventable death and disease has serious consequences, especially at a time when life expectancy has declined for Americans due to a variety of factors including COVID-19 and opioid overdoses

In addition, fluoxetines antidepressant effects require chronic administration in order to be therapeutic, suggesting postsynaptic neuroadaptations in 5-HT receptor signaling (65)

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Boyum, A., Fjerdingstad, H