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Jordan Goodman, author of Tobacco in Human History, says that as a historian he is usually wary of blaming specific people, but when it comes to smoking, I can say with certainty that James Buchanan Duke, also known as Buck Duke, is responsible for the emergence of cigarettes in the 20th century. The latter not only participated in its creation, but also developed the marketing and sales systems that made cigarettes spread to all continents

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Mechanisms of smoking-induced vascular endothelial dysfunction Figure 1 shows the putative mechanisms of smoking-induced vascular endothelial dysfunction