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Most reported symptoms lack robust causal evidence and may reflect coincidental findings or underlying conditions

[DOI] [PMC free article] [PubMed] [Google Scholar] 163.Lan Q et al

The FDA PDUFA target action date is anticipated in 2026 if submissions proceeded on schedule

The angiogenic effect is not direct on isolated cells in culture but appears in vivo when blood vessels and surrounding tissue are present (Brcic et al., 2009)