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Secondly, the timing of events in the naturalistic study was determined by the subjects, and therefore did not necessarily conform to optimal principles of fMRI experimental design 32, 33

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The findings are important because they show that even when people with MS are treated with powerful therapies such as ocrelizumab, lifestyle factors like smoking can still have a significant negative impact and may reduce the benefits of treatment

Lastly, proportional estimations of demographic variables were calculated along with their corresponding 95% confidence intervals

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